Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 21

Peripheral T‐cell lymphomas (PTCLs) collectively include neoplasms of mature (i.e. post‐thymic) T or natural killer (NK) cells. As in other cancers, the neoplastic transformation encompasses a multistep process altering pivotal cellular pathways to allow for the survival and expansion of the neoplastic clone, and the recruitment of a favorable microenvironment. Interestingly, neoplastic T or NK cells retain some features related to their cellular differentiation, which affects the clinical, pathological, and biological presentation of the diseases, as well as their outcomes. In this chapter, we review the main types of genetic alterations found in PTCL, discuss the role and importance of the tumor microenvironment and the underlying conditions favoring T‐cell transformation, and the relevance of cell‐of‐origin to T‐cell lymphoma genesis and biology.