Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 13

 The natural diversity of T cells in normal immune system functions contributes – in part – to the diversity of T‐cell malignancies.

 CD4‐positive T lymphocytes, also called T helper (Th) cells, are divided into a diverse repertoire of T lymphocytes (e.g. Th1, Th2, and Th17), in part defined by the cytokine profile they elaborate.

 Th1 and Th2 lymphocytes can also be classified based on the expression of the transcription factors T‐bet and GATA3. These factors can be prognostic in peripheral T‐cell non‐Hodgkin lymphomas derived from these cells (with GATA3 being associated with a poor prognosis).