Читать книгу The Peripheral T-Cell Lymphomas - Группа авторов - Страница 20

 The peripheral T‐cell lymphomas (PTCL) are characterized by the accumulation of mutations in genes that govern multiple epigenetic pathways, with some entities like PTCL‐follicular helper T cell and angioimmunoblastic T‐cell lymphomas (AITL), representing the subtypes most enriched for these genetic events.

 Mutation‐induced activation of signaling pathways that play a key role in normal T and natural‐killer (NK) cell physiology, like the Janus kinase/signal transducers and activators of transcription pathway or T‐cell receptor signaling, are highly recurrent and common to many entities.

 Extranodal NK/T‐cell lymphoma and adult T‐cell leukemia/lymphoma represent two remarkable models lymphomas induced by viruses with superimposed genetic lesions.

 The tumor microenvironment, and the nature of its cellular milieu, plays an important role in PTLC lymphomagenesis, especially in AITL.