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Preface to the Second Edition

Basic biologic research in orthodontics has witnessed rapid growth since the publication of the first edition of Biological Mechanisms of Tooth Movement. This research not only identified biologic factors associated with tooth movement and its iatrogenic reactions but has expanded even deeper into exploration at the molecular and genomic levels, to generate new knowledge that can be used in clinical settings.

The concept of personalized or individualized medicine is rapidly gaining a hold in medicine as may be seen from the global annual conferences on this subject. In medicine, at this time, the focus is on the personal determinants of cancer and diabetes. Efforts to adapt this concept to all of medicine are gaining momentum. Dentistry is no exception, and orthodontics is potentially the pioneer in this regard. Orthodontists have long been customizing their diagnoses and treatment plans according to the physical characteristics of their patients but now we are entering a period when it would be possible to evaluate the biological features of each patient, by measuring specific tissue markers in fluids, such as saliva and gingival crevicular fluid. The task of establishing reliable tests for the identification of the sought‐for markers may not be imminent because of the complexity and variability of the individual genomics but investigations of this pathway have already begun.

The role of basic biologic research has frequently been portrayed as the identification of factors and processes that participate in clinical functions, and test the validity of any hypothesis regarding the efficacy and safety of new and old clinical methods. The specialty of orthodontics has benefitted from this relentless flow of new information, derived from a plethora of publications in numerous scientific periodicals, which focused on mechanism of mechanotransduction, the birth, life and death of the osteoclast, the molecular genetics of bone modeling and remodeling, and the effects of hormones and drugs on soft and mineralized connective tissues. This ongoing growth in information is already affecting clinical orthodontics. One major concept gaining support is the proven ability of bone and periodontal fibroblastic cells to respond simultaneously to more than one signaling factor. Evidence in support of this principle has already led to the application, in addition to orthodontic force, of surgical procedures, vibrations, laser radiation, electricity, and vitamin D3. All of these factors have displayed an ability to enhance the velocity and reduce the duration of tooth movement. The orthodontist now has at his/her disposal a choice of methods, invasive and noninvasive, local and systemic, that can augment the pace of tissue changes that facilitate tooth movement. These mechanisms act on the tissue and cellular levels, and can be manipulated based on increasing knowledge derived from worldwide laboratory experiments and clinical trials, all of which elevate the clinical potential of orthodontics to attain positive results, with a long‐range stability, and with a low risk for undesirable side effects.

We are pleased to present this second edition of Biological Mechanisms of Tooth Movement, in which we have assembled chapters about topics closely related to the basic biologic aspects of orthodontics, which affect the movement of teeth during orthodontic treatment. It updates most of the subjects addressed in the first edition, and includes new topics, such as the search for efficient methods to accelerate tooth movement.

We would like to thank all our contributors who have demonstrated dedication to this project. We would also like to express our sincere appreciation to the book reviewers, who critically analyzed the first edition of the book and let us know its shortcomings so that the second edition is made much stronger. We express our gratitude to our publisher, Wiley‐Blackwell, especially Sophia Joyce, Hayley Wood, Jessica Evans, Sara Crowley‐Vigneau, and Katrina Hulme‐Cross, who helped us complete the project successfully. We would also like to thank the support staff, Jayavel Radhakrishnan, David Michael and all others, who worked tirelessly to facilitate this publication.

As we have stated in the preface to the first edition of this book, “we really hope that this compendium will convince the readers that the dentofacial complex is an integral part of the complete human body, and as such, is prone to be influenced by any factor, genetic or environmental, like any other region of the body.” Orthodontic academicians and clinicians increasingly recognize this principle and try to treat patients as humans, not merely as typodonts. We hope that this book will assist all orthodontists in this effort.

Vinod Krishnan Ze’ev Davidovitch Editors