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Systemic Antibiotics

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Intravenous antibiotics, usually carbapenems, are the first step in the treatment of infected pancreatic necrosis. Antifungal agents are not consistently recommended. About 15–30% of patients respond well to this conservative approach and do not require any invasive intervention [33,34]. How long antibiotic therapy should be maintained is an open question that should be evaluated in each individual patient. If clinical and laboratory markers of sepsis do not improve after 48–72 hours of antibiotic therapy, infected WON should be drained.

Clinical Pancreatology for Practising Gastroenterologists and Surgeons

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