Читать книгу Clinical Pancreatology for Practising Gastroenterologists and Surgeons - Группа авторов - Страница 31

In 1878, Cawley [38] first described the association by using the term “drunkard pancreatitis.” A case–control study from Japan showed that the odds ratio for development of pancreatitis increased after consumption of more than 20 g/day of alcohol. With subsequent incremental dose of alcohol intake, the odds ratio increased further to 6.4 with an alcohol consumption of more than 100 g/day [39]. A recent meta‐analysis and systematic review demonstrated a dose–response relationship between alcohol consumption and the risk of development of pancreatitis (both acute and chronic pancreatitis). Despite this evidence, alcoholic pancreatitis occurs in less than 10% of heavy drinkers [40]. The drinking pattern and lifetime alcohol intake are similar in patients with alcoholic pancreatitis and asymptomatic heavy drinkers [41]. These observations suggest that there are other factors which either make the pancreas susceptible (e.g. genetic predisposition) or act as a cofactor (e.g. tobacco use) [40,42].