Читать книгу Clinical Pancreatology for Practising Gastroenterologists and Surgeons - Группа авторов - Страница 34

Hypertriglyceridemia (HTG) is another uncommon but important metabolic cause of AP. Serum triglyceride levels above 1000 mg/dl can cause pancreatitis. Even lower levels may be associated with a higher risk of AP. The mechanism of pancreatitis due to HTG is not fully understood. Most patients with severe HTG have an underlying familial disorder of lipid metabolism, which needs further evaluation. Since only some patients with HTG develop AP, a cofactor may be required to cause pancreatitis. A higher frequency of CFTR mutations has been reported in HTG‐induced pancreatitis [44]. In alcoholic pancreatitis, serum triglyceride level can be elevated during an acute episode. Insulin with heparin and plasmapheresis have been shown to be beneficial in lowering lipid levels and improving the course of pancreatitis [45,46]. A newer therapy has been introduced in the form of an antisense molecule known as volanesorsen [47].