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Acute interstitial edematous pancreatitis (IEP) is the most common form of acute pancreatitis, found in 75% of patients. IEP consists of gland edema and inflammation, and is typically a self‐limiting disease with favorable outcomes. The parenchymal signal intensity of acute pancreatitis slightly differs from that of normal pancreatic tissue. There can also be focal or diffuse gland enlargement, and T1‐weighted images demonstrate decreased signal in the gland. T2‐weighted images using fat signal suppression are the most sensitive for edema, and show high signal fluid in a background of intermediate to low signal pancreas and low signal fat (Figure 6.1a). The sensitivity of MRI exceeds that of CT, suggesting a role for MRI in the evaluation of patients with suspected acute pancreatitis and negative CT imaging examination [6]. Peripancreatic fat stranding is commonly seen as low signal on T1‐weighted and high signal on T2‐weighted images. In more severe forms of IEP, peripancreatic fluid collections may be seen as organized areas of increased T2 signal. IEP will also show decreased enhancement on post‐contrast images T1‐weighted images (Figure 6.1b) [7]. MRCP images of IEP often depict no dilatation of the main pancreatic and the majority of cases show small diameter of the pancreatic duct due to parenchymal edema.