Читать книгу Handbook of Clinical Gender Medicine - Группа авторов - Страница 126

There is strong evidence for familiality in major depression, and men and women appear to share most but not all genetic influences for the disorder [14]. Certain sex-linked traits may play a role; for example, the uVNTR polymorphism of the MAOA gene on the X chromosome has been found to confer vulnerability to depression more in women than in men [15]. Similarly, estrogen receptor-beta (ER-β) appears to play a role in anxiety: Krezel et al. [16] reported an increase in anxiety-related behaviors in ER-β knockout female mice but not in males.