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What Should I Do if I Am Not Sure whether the Disease Is Active?

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In this situation management will depend on the presenting features and their severity. Unless there is clear evidence to the contrary, all sight-threatening features should be assumed to be of recent onset, implying active disease and a need for urgent intervention. At the other end of the spectrum, patients who present with only eyelid retraction and mild exophthalmos do not require any urgent intervention and can safely be sequentially assessed until their disease phase is apparent and any necessary therapy then offered.

Graves' Orbitopathy

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