Читать книгу Graves' Orbitopathy - Группа авторов - Страница 69

Orbital fibroblasts include a subpopulation of cells (preadipocytes and/or mesenchymal stem/stromal cells) which may differentiate into adipocytes [4–6]. De novo adipogenesis in orbital adipose/connective tissue is demonstrated by an increase in the “adipocyte-related immediate early gene” mRNAs, including the angiogenic inducer, followed by increased expression of peroxisome proliferator-activated receptor-γ (PPAR-γ), adiponectin, leptin, and stearyl-CoA-desaturase [7]. In vitro, orbital fibroblasts differentiate into adipocytes when treated with PPAR-γ agonists, e.g., rosiglitazone, in keeping with the observations of GO progression in 1 patient [8] and mildly increased eye protrusion in type 2 diabetes patients [9] treated with pioglitazone.