Читать книгу Intracranial Gliomas Part II - Adjuvant Therapy - Группа авторов - Страница 37

The prognostic significance of various molecular alterations in pediatric gliomas is less clear. Presence of the H3F3A^K27M mutation indicates malignant tumor behavior independent of the histological appearance [14, 39]. Mistry et al. [39] performed a retrospective population-based long-term study evaluating 26 secondary HGG and their predecessors in children and proposed the following molecular/clinical markers of LGG:

•BRAF-KIAA1549 fusion without accompanying alterations of TP53, CDKN2A, and BRAF^V600E (excellent long-term outcome and extremely low risk of malignant transformation);

•TP53-mutant, CDKN2A-deleted, or BRAF^V600E-mutant (high risk of malignant transformation);

•Origination in patients with cancer predisposition syndromes (tumor will eventually undergo malignant transformation);

•Midline tumors carrying H3F3A^K27M mutation (exhibit biological behavior similar to primary HGG).