Читать книгу Metabolic Syndrome Consequent to Endocrine Disorders - Группа авторов - Страница 31

The chronic excess of growth hormone (GH) and insulin-like growth factor-1 (IGF-1) that occurs in acromegaly affects virtually all aspects of metabolism, including protein, lipid, and carbohydrate synthesis and degradation as well as the handling of sodium, calcium, and phosphorus by the kidney. The clinical expression of these metabolic abnormalities varies among patients and is strongly influenced by ethnogentic and environmental factors. The resulting co-morbidities, including diabetes, dyslipidemia, and hypertension, contribute to the increased cardiovascular mortality risk found in these patients. In this brief review, we analyze the pathophysiology, epidemiology, and clinical characteristics of the carbohydrate and lipid metabolism abnormalities that occur in acromegaly. For an in-depth analysis of the effects of chronic GH and IGF-1 excess on the renal handling of sodium, calcium and phosphorus we refer the reader to an excellent review by Kamenicky et al. [1].