Читать книгу Metabolic Syndrome Consequent to Endocrine Disorders - Группа авторов - Страница 35

Acromegaly is associated with lipid and carbohydrate metabolism abnormalities. Both GH and IGF-1 have a role in increasing insulin resistance and altering glucose and lipid mobilization. The end result is a significant predisposition to glucose intolerance and diabetes and an adverse lipid profile with higher triglyceride and lower HDL levels, as well as the presence of denser and more atherogenic LDL particles. Successful treatment of acromegaly results in significant improvements in this adverse metabolic profile, although a complete normalization of glucose and lipid metabolism is seldom achieved, which likely reflects the co-existence of other risk factors such as the ethnic background of the population and the concomitant presence of hypopituitarism.