Читать книгу Intracranial Gliomas Part III - Innovative Treatment Modalities - Группа авторов - Страница 9

With this, the third of three consecutive volumes of Progress in Neurological Surgery devoted to current management of intracranial gliomas, we present to the medical community Part III, dedicated to innovative treatment modalities. At present most intracranial gliomas are considered incurable with current therapeutic strategies. As a result, ongoing investigations continue the search for new methods that may more effectively control tumor growth.

In the opening chapter Kaneko et al. discuss clinical applications of photodynamic therapy in the management of malignant brain tumors and share their extensive clinical experience with this technique. Thermotherapy of intracranial gliomas performed by means of hyperthermia or cryodestruction is presented by Karampelas and Sloan, and Martynov et al. Alkins and Mainprize review therapeutic capabilities of focused ultrasound, which may be applied for tumor ablation, blood-brain barrier disruption, and radiosensitization. Two subsequent chapters describe innovative techniques of glioma irradiation, namely boron neutron capture therapy (by Miyatake et al.) and proton and carbon ion therapy (by Combs). Butowski presents perspectives of molecular targeted therapy for brain tumors. The reviews that follow highlight advances of glioma treatment with cytokines (by Iwami et al.), cell-based immunotherapy (by Everson et al.), vaccines (by Ishikawa et al.), gene transfers and viruses (by Kim et al.), and stem cells (by Parker Kerrigan et al.). Prabhu and Paldor et al. describe variable techniques of local drug delivery in cases of intracranial gliomas and discuss the results of such treatment. Santiago- Dieppa et al. highlight therapeutic potentials of extracellular vesicles for possible use in neuro-oncology. Wong et al. present the evolution of alternating electric fields, also known as Tumor Treating Fields (TTFields), from the initial laboratory observations to approved treatment of patients with glioblastoma. Finally, Yoon et al. highlight promising clinical applications of bionanotechnology in the diagnosis and management of brain tumors.

Many of the presented novel therapeutic modalities have already demonstrated antitumor efficacy in clinical testing, whereas others are still under development. It is highly expected that their application may change the current paradigm of glioma treatment and significantly improve its results.

Our thanks, first and foremost, go to the many contributors to this volume who agreed to share their knowledge and clinical experience, and who dedicated their time to preparing the manuscripts; and to the team at Karger Publishers who provided superb organizational assistance throughout the realization of this publication project. While preparing the book for publication we have tried to be comprehensive and succinct in our review of the literature to make it useful for (and accessible to) all types of readers. We hope the materials presented herein and in the two accompanying volumes of Progress in Neurological Surgery (Intracranial Gliomas Part I – Surgery and Part II – Adjuvant Therapy) will carry practical and scientific interest for neurosurgeons, radiation oncologists, neuro-oncologists and other clinicians treating patients with brain tumors, as well as for both clinical and basic researchers working in the related fields.

Mikhail F. Chernov, MD, DMedSci, Tokyo

Yoshihiro Muragaki, MD, PhD, Tokyo

Santosh Kesari, MD, PhD, FANA, FAAN, Santa Monica, CA

Ian E. McCutcheon, MD, CM, FRCS(C), FACS, Houston, TX