Читать книгу Disorders of Fluid and Electrolyte Metabolism - Группа авторов - Страница 11

The ability to measure plasma concentrations of AVP was a major advancement, as this allowed definition of the characteristics of the regulation of secretion of the antidiuretic hormone for the first time [10, 11]. Prior to the development of sensitive radioimmunoassays for the measurement of AVP in plasma, our knowledge of the physiology of AVP release and action was implied from the use of urine osmolality as a bioassay for the action of AVP. In the 1970s, a number of specific antibodies to AVP were developed from animal models, and used to develop sensitive radioimmunoassays, which were used in clinical studies to measure AVP in plasma and urine [9]. Using these new assays, researchers defined the physiology of AVP secretion in response to osmotic and non-osmotic stimuli [12]. With particular relevance to hyponatremia, Robertson et al. [13] were able to demonstrate that plasma AVP concentrations were elevated in >90% of cases of SIAD [13], thus proving the clinical hypothesis made by Schwartz et al. [6] 25 years earlier.