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Differential Diagnosis

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Melanoma at these locations should be differentiated from metastatic melanoma and primary undifferentiated skull base neoplasms, including sinonasal undifferentiated carcinoma, neuroendocrine tumour, olfactory neuroblastoma, lymphoma, PNET, and rhabdomyosarcoma. Immunohistochemical markers are fundamental in differentiating these tumours (Table 2).

Anterior Skull Base Tumors

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