Читать книгу Anterior Skull Base Tumors - Группа авторов - Страница 65

Sinonasal and skull base paragangliomas are extremely rare. They are likely to be derived from dispersed neuroendocrine cells within the sinonasal mucosal covering. Tumours at this location may behave in an aggressive fashion. All paragangliomas are considered malignant in the new WHO classification.

The histologic characteristics of these lesions are typical of those in traditional sites with classical Zellballen organisation and granular cytoplasm [118–120]. Immunohistochemically, cells comprising these tumours are positive for neuroendocrine markers and negative for keratin. A helpful feature is the positivity for S-100 protein in sustentacular cells bordering the Zellballen.