Читать книгу Anterior Skull Base Tumors - Группа авторов - Страница 44

Rhabdomyosarcoma is a rare form of sarcoma with skeletal muscle differentiation [58–63]. There are three main histological subtypes that include embryonal, alveolar, and pleomorphic variants. The most commonly encountered subtype in the sinonasal site is the embryonal form, which mainly affects the paediatric age. In adults, the alveolar subtype is more common than the embryonal form. Histopathologically, immunohistochemical markers are crucial to detect primitive skeletal muscle differentiation. Genetically, only the alveolar subtype harbours fusion genes (PAX3-FOXO1 and PAX7-FOXO1) [64–66].