Читать книгу Oral Biofilms - Группа авторов - Страница 59

Artificial subgingival biofilms can be generated in the microbiology laboratory in order to study their behavior in vitro and deduce conclusions for their behavior in vivo. These biofilm models can be clinically very useful in understanding the role of different biofilm bacteria in the pathogenesis of diverse diseases and in testing the antimicrobial efficiency of different antimicrobial agents prior to clinical application. According to earlier studies [18], there are several requirements that should be met by a good model system. Most importantly, results generated by the model system should be reproducible.

Due to the enormous microbial complexity of periodontal disease, there are several obstacles to overcome in order to successfully build a sufficient model system. The overwhelming amount of different bacterial species, as well as the morphological diversity, is a limiting factor that restricts the accurate matching of the in vivo situation with a biofilm model system.