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Diagnosis of ALS

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To date, there are no reliable diagnostic tests for ALS, and clinicians rely on the clinical evidence of a combination of UMNs and LMNs in the same body region, electromyographic confirmation of ongoing LMN degeneration, and the exclusion of mimicking conditions. Motor multifocal neuropathy, Kennedy disease, inclusion body myopathy, Sandoff disease, Morvan syndrome, paraneoplastic encephalomyelitis, inflammatory multineuropathies, and compressive myelopathies are conditions that may be confused with ALS and should be accurately evaluated. Criteria for the diagnosis of ALS have been established and are known as the El Escorial criteria, but they are more useful in the research field than in the clinical setting [14, 15].

Spectrums of Amyotrophic Lateral Sclerosis

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