Читать книгу Spectrums of Amyotrophic Lateral Sclerosis - Группа авторов - Страница 22

Recent genetic discoveries and progress in neuropathology have completely changed the perspective on ALS. The current idea is that ALS cannot be considered a single entity (as it was until a few years ago) but rather is part of a clinical spectrum of disease. Various clinical manifestations can be described depending on familial history, age of onset, site of onset, disease duration, and overlap with other conditions as cognitive impairment or myopathies. Animal and cellular models have been established to better characterize the disease pathogenesis and to link the disease to different biological pathways. All these models have the same goal: looking for treatments that can stop or at least significantly slow the disease progression.