Читать книгу The Esophagus - Группа авторов - Страница 34

Recurrent noncardiac chest pain (NCCP) is a common clinical scenario with a global prevalence of up to 13%, with related expenditures exceeding $10 billion annually in the United States [1, 2]. Beyond the musculoskeletal etiologies, the majority are esophageal in origin [3]. Recognizably, esophageal chest pain (ECP) manifests from a heterogeneous group of causes, albeit only some of which are well understood. Among these, gastroesophageal reflux disease (GERD) is the primary etiology for approximately 50% of cases, whereas other causes include esophageal hypersensitivity, functional gastrointestinal (GI) disorders, and esophageal dysmotility [4–6]. This discussion will highlight the most recent available evidence‐based literature on the epidemiology, pathophysiology, and treatment of GERD, esophageal hypersensitivity, and esophageal dysmotility as they relate to ECP.^* Additionally, a practical clinical algorithm is provided with evidence‐based recommendations for treatment and diagnosis.