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Early identification of at‐risk pregnancies can improve outcomes through more careful monitoring and early intervention, and thus there is great interest in determining whether there are clinically relevant and assessable markers of this risk to aid early intervention. Administration of low‐dose aspirin prior to 16 weeks of gestation has been linked to reduced risk for PE.^{105, 106} Once symptoms occur, antihypertensive and/or anticonvulsant medication may be prescribed, although ultimately only delivery of the baby can cure the disease.

A number of biomarkers quantifiable in maternal blood have been investigated for utility in prediction of PE. An increase in sFLT‐1 and decrease of free vascular endothelial growth factor (VEGF) and PlGF are found in the blood of some women in the first trimester prior to the onset of PE.^{107, 108} Abnormal levels of endoglin (involved in vascular remodeling) have also been observed, and it has been suggested that PE may be the result of an imbalance between pro‐ and antiangiogenic factors.¹⁰⁹ Other factors that have been reported as altered in the serum of pregnant women with or at risk of PE include leptin, ADAM12, PP13, PlGF, PAPP‐A, and inhibin‐A. A screening approach using maternal risk factors (e.g. advanced maternal age, increased weight, previous pregnancy with PE), combined with the uterine artery pulsatility index, mean arterial pressure, and maternal serum markers (PlGF and PAPP‐A), has been reported to detect 95 percent of EOPE with a 5 percent false‐positive rate.¹¹⁰ As all associated biophysical and serum markers are correlated with each other in PE, this needs to be accounted for in the models. It is important to appreciate that the factors contributing to PE may vary by population, and this model needs to be validated in other populations. Furthermore, the predictive value for LOPE is much lower than for the more severe early‐onset form. These factors may explain why other studies suggest less clear predictive benefits of individual serum markers, although combinations of markers may prove useful for early screening.^{111, 112}