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Box 4.2 Summary of the sources searched for an IPD meta‐analysis of randomised trials examining recombinant human bone morphogenetic protein‐2 for spinal fusion.

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 Cochrane Central Register of Controlled Trials

 MEDLINE 1948 to present

 EMBASE 1974 to present

 Science Citation Index 1899 to present

 Automated “current awareness” searches to June 2012

 ClinicalTrials.gov (to identify ongoing or unpublished randomised trials)

 Published a call for evidence

Source: Lesley Stewart, listing the sources used by Simmonds et al.,65 with permission.

The screening process for deciding which trials are relevant for inclusion is very similar to that for standard systematic reviews.92 However, with IPD meta‐analysis projects, because there is usually greater contact with trial investigators, any doubt as to the eligibility of a particular trial (e.g. in relation to whether particular variables or outcomes are recorded in the trial’s IPD) can be clarified through discussion. This process should be well documented, so that it can be used to help populate a PRISMA‐IPD flow diagram (Chapter 10).60

Individual Participant Data Meta-Analysis

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