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4.4.3 Transferring Trial IPD Securely

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Based on the relevant data transfer guidance supplied by the central research team, secure data transfer can be achieved using a suitable file transfer site, for example, an institutional or suitable commercial file share service. Where a data file needs to be sent via email, ideally it should be end‐to‐end encrypted or otherwise password protected, with passwords sent separately (and ideally via a different communication medium, such as by post or by telephone). Although rare these days, if data need to be transferred using physical storage media, such as external disc drives or memory sticks, these should also be encrypted and sent using a delivery service that allows the package to be tracked and signed for upon delivery.

When data files are first received, it is important to ensure that they can be read and loaded into the preferred storage or analysis system before proceeding. For example, if a data file arrive electronically, it should be checked to ensure that any passwords provided work, and that it can be opened, is for the correct trial, and that the data have not been corrupted during transfer. It is important to thank relevant trial personnel for providing their data, and either confirm that they are as expected, or relay any issues that have arisen, as soon as possible.

Individual Participant Data Meta-Analysis

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