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Cellulose is also very sensitive to external stimuli. An excellent review on stimuli responsive materials discussed the applications of pH, redox, temperature, light, and mixed stimuli on the controlled release of molecules from cellulose matrices [132]. It also finds applications as DNA delivery vehicles including DNA vaccines [133–136]; cellulose is investigated as suitable agents for oral delivery of DNA [137], which is fraught with complications due to the involvement of the gastro-intestinal tract.