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Pathology of the Salivary Glands

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Pathologic states of the salivary glands include tumors (epithelial and non‐epithelial), infections and inflammation, autoimmune diseases, vascular lesion, and non‐salivary tumors.

Of all salivary gland tumors, most (80%) are found in the parotid gland. The submandibular gland contains approximately 10% with the remainder in the sublingual and minor salivary glands. Of all parotid gland tumors, 80% are benign and 20% malignant. About 50% of submandibular gland tumors are benign and most of sublingual gland tumors are malignant. About 50% of minor salivary gland tumors are benign. The smaller the gland, the more likely that a mass within it is malignant. The pleomorphic adenoma and papillary cystadenoma lymphomatosum (Warthin tumor) account for most of benign salivary tumors, with the former being the more common at about 80% of benign and latter less common at about 15% of benign masses. Most of the malignant salivary gland tumors are represented by mucoepidermoid and adenoid cystic carcinomas.

Malignancies of the parotid gland may result in metastatic involvement of intraparotid and adjacent level II, and III jugular chain lymph nodes. The SMG drains primarily into adjacent level IB lymph nodes and then into the jugular chain and deep cervical nodes. The SLG drains into both level IA and IB nodes and then subsequently into the jugular chain and deep cervical nodes.

Salivary Gland Pathology

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