Читать книгу Genetic Analysis of Complex Disease - Группа авторов - Страница 20

Several types of observational designs may be considered for population‐based studies, including case‐series, case–control, and longitudinal cohort designs. The possible sampling frames for these types of studies include simple random samples of a defined geographical area, clinic‐ or hospital‐based samples, convenience samples such as voluntary registries or biobanks, or hybrids of these (e.g. health‐system‐based biobanks linked to longitudinal electronic health records). These designs became much more frequent with the advent of high‐throughput genotyping technologies, which enabled the efficient study of very large samples of unrelated individuals through GWAS (Chapter 9), an approach with substantially greater power than a similarly sized family‐based study.