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Patient safety and quality are now familiar terms, given the work of many outstanding health care leaders over the past 20 years. The work is not finished. Ricciardi (2021) looks ahead from 2020 to 2030, with goals for implementing evidence and developing tools and strategies to help health systems and front‐line health care workers deliver safe, high‐quality, high‐value, accessible health care that is equitable and affordable, as first called for in the IOM 2001 report. This will require the commitment and passion of all health care workers to develop methodologies, new knowledge and initiatives, and system‐wide capacity intended to improve quality and safety across the continuum of care. How will each of us answer this and the aims in the 2020 Safer Together National Safety Plan? David Mayer, MD and CEO of the Patient Safety Movement Foundation, set an ambitious agenda in asking for a “Moonshot” to achieve the goals set 20 years ago and updated in subsequent reports (Textbox 1.7). No one can do it alone, patient safety truly is a team sport, but working together we can “shoot for the stars,” to keep every patient and every worker safe if all of us make the commitment.