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 The most widely used regimen is the administration of 4 drugs (isoniazid, rifampicin, pyrazinamide, and ethambutol) for 2 months, followed by 2 drugs (isoniazid and rifampicin) for another 4 months

 Multidrug‐resistant tuberculosis is an increasing concern – the disease does not respond to isoniazid and rifampicin, the 2 most powerful medications used to treat the disease

 Alternatives in this situation include diarylquinoline and nitroimidazole

 Treatment regimens can be prolonged, typically lasting 6–12 months

 Treating recurrent tuberculosis that is caused by relapse is challenging as often the bacteria have become resistant to treatment and a different combination of drugs, taken over a longer period of time, is required

 Hence recurrent tuberculosis disease is associated with poor treatment outcomes and higher mortality rates compared to primary tuberculosis infection