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 Varies significantly (Table 5.2.2). Enlargement of the thyroid gland (goitre) can occur due to overstimulation in response to low thyroid levels (Figure 5.2.3)

 Determined by age, sex and progression time

 Ranges from asymptomatic forms to myxoedema crisis/coma (encephalopathy, hypothermia, seizures, hyponatraemia, hypoglycaemia, arrhythmias, cardiogenic shock, respiratory failure and fluid retention)

 Cretinism, classically the result of maternal iodine deficiency, is associated with growth retardation, developmental delay, mental retardation and thickened facial features