Читать книгу Spiro Compounds - Группа авторов - Страница 22

Over the past decades, transition‐metal catalysis has emerged as a powerful tool for the construction of complex molecules. Also, rigid and strained chiral scaffolds have been synthesized in a straightforward manner under catalytic routines. Across these molecules, spirocompounds represent an important structural family with diverse and specific biological activity. In the following pages, it will be demonstrated how transition metals have overcome the synthetic issues connected to the assembly of the rigid all‐substituted quaternary sprirocenter. Drawbacks of some transition‐metal‐based catalytic systems remain the relatively low stability under aerobic conditions, while the most recent transformations have found important applications in concert with organocatalytic approaches. The section has been divided into three subcategories according to the involved reactions: [3+2] cycloaddition, [4+2] cycloaddition, and miscellaneous reactions.