Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 367

NPY is synthesized in the peripheral nervous system and brain and strongly stimulates food intake. There is preliminary evidence from animal studies that ageing may be associated with reduced NPY activity, perhaps more in males than females. Old rats have lower levels of arcuate nucleus prepro‐NPY mRNA than young rats, and hypothalamic NPY levels decrease with ageing in male but not female rats. Studies in humans, however, suggest, if anything, increased NPY activity with increasing age. CSF NPY levels increase with healthy ageing in women, and plasma and CSF levels are increased in elderly people with idiopathic anorexia. In rats, the feeding response to hypothalamic NPY injections diminishes with ageing, whereas the stimulation of feeding by intracerebroventricular NPY administration in mice does not diminish with age. The effects of NPY administration in humans have not been reported. Therefore, there is currently no convincing evidence for an involvement of NPY in the human anorexia of ageing.³⁶