Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 397

The first response of caregivers to weight loss, whether due to starvation or to cachexia, is to increase nutrient intake. Decreased incidence of pressure ulcers during hospital stays was shown with oral supplementation.⁶⁷ In a meta‐analysis of 42 trials, nutritional supplementation produced a mean difference in weight gain of 2.3%. Reduced mortality was observed in the supplemented compared with control groups (relative risk [RR] = 0.74; 95% CI 0.59–0.92) in 32 trials. The subgroup analyses suggested that the effects on mortality were consistently significant when limited to trials in which participants were defined as undernourished (RR = 0.72; 95% CI 0.55–0.94), when 400 kcal or more was offered per day in the supplement (RR = 0.71; 95% CI 0.56–0.90), when participants were at least 75 years old (RR = 0.69; 95% CI 0.54–0.87), when supplementation was continued for 35 days or more (RR = 0.75; 95% CI 0.56–1.00), when participants were unwell (RR = 0.73; 95% CI 0.59–0.92), and when participants were in the hospital or a nursing home (RR = 0.67; 95% CI 0.52–0.86). However, there was no evidence of improved functional status or reduction in length of hospital stays with supplements.⁶⁸ Nutritional advice given to older patients at risk for malnutrition during the chemotherapy period increased energy and protein intake as compared to routine care but did not modify mortality or quality of life.^54,69 In older patients treated for cancer, a nutritional care plan integrated with global geriatric care is recommended.⁷⁰

In nursing homes or long‐term care homes, nutritional support should be organized both at the resident level and at the institutional level.^71,72

A failure to consume adequate nutrients or supplements often leads to enteral feeding. Enteral feeding can frequently be life‐saving, but improving nutritional parameters is difficult to verify.⁷³ There is little evidence for benefit in survival or comfort for enterally fed patients with weight loss due to cancer cachexia, and there are substantial associated risks, discomforts, and costs.⁷⁴ Enteral feeding in nursing home residents older than 65 with severe cognitive impairment did not affect survival at 24 months compared with residents who were not enterally fed.⁷⁵ In nursing homes, only long‐term percutaneous enteral feeding was associated with increased survival. Adverse events such as aspiration pneumonia occurred at a similar rate with or without enteral feeding.⁷⁶ The results of percutaneous parenteral feeding in subacute patients was not optimal.⁷⁷ Survival in other medical conditions does not appear to be affected by enteral feeding. A downward trend in the use of parenteral nutrition in critical care patients has occurred over the last few years, chiefly due to studies showing higher morbidity with parenteral nutrition compared with enteral nutrition.⁷⁸

Undernourished or high‐risk surgical patients did not have postoperative complications reduced to that of well‐nourished patients undergoing similar procedures by enteral or parenteral support.⁷⁹ These data suggest that factors other than pure starvation are operational since a response to refeeding is the hallmark of starvation.