Читать книгу Pathy's Principles and Practice of Geriatric Medicine - Группа авторов - Страница 604

Maintaining an INR within the optimal range is more complicated as age increases, and labile INR is a risk factor for bleeding.⁶⁴ Reduced time in therapeutic range (TTR, percentage of time a patient’s INR is within the desired therapeutic range, using the linear interpolation method of Rosendaal) is related to higher mortality. When the INR is not suitably controlled (considering TTR <65% in the last six months), changing the anticoagulant treatment should be considered.

Left atrial appendage closure could be a viable alternative to oral anticoagulation therapy for patients with NVAF who are considered poor candidates for long‐term oral anticoagulation or have any absolute contraindication. There is no current consensus on its indications and patient and device selection.⁶⁵