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Veterinary Surgical Oncology
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Страница 1
Table of Contents
List of Tables
List of Illustrations
Guide
Pages
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1 Principles of Surgical Oncology
Preoperative Considerations Signalment
Staging/Concomitant Disease
Neoadjuvant Therapy
Surgical Planning
Fine Needle Aspirate
Biopsy
Pretreatment Biopsy
Needle Core Biopsy
Punch Biopsy
Incisional (Wedge) Biopsy
Excisional Biopsy
Specific Biopsy Techniques
Bone Biopsy
Lymph Node Biopsy
Endoscopic Biopsy
Surgical Considerations for Curative‐Intent Surgery
Defining and Evaluating Surgical Margins
Varying Definitions of “Margin”
The Influence of Sectioning
Future Directions
Palliative and Cytoreductive Surgery
Postoperative Considerations Tissue Marking
Guidelines for Fixation of Surgical Tissue Specimens
Frozen Sections
Wound Healing
Adjuvant Therapy
References
2 Multi‐modal Therapy
Introduction
Surgery
Radiation Therapy
Surgery and Radiation
Chemotherapy
Electrochemotherapy
Molecular and Targeted Therapies
Complications of Chemotherapy Chemotherapy Extravasation
Guidelines for Doxorubicin Extravasation
Chemotherapy Effects on Wound Healing
Complications of Radiation Therapy Radiation Side Effects
Impact of Radiotherapy on Surgical Outcome
Timing of Radiation Therapy Relative to Surgery
Skin Grafts and Flaps in the Radiation Field
Bone Healing and Radiation Therapy
Minimizing the Negative Impact of Radiotherapy on Surgery
References
3 Interventional Oncology
Imaging
Modalities
Contrast Agents
Instrumentation and Implants Access Needles
Guidewires
Sheaths
Catheters
Vascular Closure Devices
Vascular Occlusion Agents and Devices
Particles
Liquids
Coils
Balloons
Stents
Approaches Vascular
Natural Orifices
Nonvascular Interventional Oncology Techniques Stents Tracheobronchial Neoplasia
Ureteral Neoplasia
Bladder, Urethral, and Prostatic Neoplasia
Colorectal Neoplasia
Esophageal Neoplasia
Biliary Neoplasia
Percutaneous Drainage Malignant Body Cavity Effusions
Other Drainages
Tumor Ablation
Vascular Interventional Oncology Techniques Stents
Intraarterial Chemotherapy
Transarterial Embolization and Chemoembolization
References
4 Skin and Subcutaneous Tumors
Skin Tumors General Principles Introduction Prevalence
Classification
General Approach to the Diagnosis and Staging of Skin Tumors Preoperative Assessment History and Physical Examination
Tumor Staging
Assessment of the Cutaneous Mass
FNA Cytology
Biopsy
Needle Core Biopsy
Incisional Biopsy
Excisional Biopsy
Regional Lymph Node Assessment
Preoperative Diagnostic Imaging
Treatment Options for Skin Tumors
Principles of Surgical Excision
Surgical Margins
Margin Evaluation
Reconstructive Procedures
Adjunctive Therapies for Skin Tumors
Mast Cell Tumors
Clinical Presentation
Diagnosis of MCTs
Clinical Staging
Treatment of Canine Cutaneous MCTs
Surgery
Perioperative Management
Margins
Surgical Margins
Regional Lymph Node Treatment
Anatomical Site Considerations
Prognostic Factors Histologic Parameters
Grade
Mitotic Index
Proliferation Indices
Clinical Stage
Size
Anatomical Location
Multiple Cutaneous MCT
Subcutaneous MCT
Postoperative Recommendations Completely Excised MCTs
Incompletely Excised MCTs
Local Tumor Recurrence
Radiation Therapy for MCT
Electrochemotherapy
Chemotherapy for MCT
Combination Chemotherapy
Deionized or Hypotonic Water
Tyrosine Kinase Inhibitors
Feline Cutaneous MCT
Mesenchymal Tumors and Melanoma Introduction
Soft Tissue Sarcomas
Incidence and Predisposing Factors
Clinical Signs
Metastasis
Diagnostic Strategies and Preoperative Planning
Novel Diagnostic Imaging Techniques
Staging and Grading
Surgical Aspects
Reconstructive Surgery
Cryosurgery
Adjuvant Therapies
Radiotherapy
Chemotherapy
Immunotherapy
Palliative Procedures
Prognosis
Specific Soft Tissue Sarcomas Fibrosarcomas
Peripheral Nerve Sheath Tumors
Perivascular Wall Tumors
Myxosarcoma
Cutaneous Hemangiosarcoma
Lipoma
Infiltrative Lipomas
Liposarcoma
Lymphangiosarcoma
Leiomyoma and Leiomyosarcoma
Melanoma
Feline Injection‐Site‐Associated Sarcoma (FISAS)
References
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