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Define and refine the system

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Diarrhoea can be due to primary disorders of the small bowel and/or large bowel or due to other systemic, secondary GI disorders such as hepatic disease, exocrine pancreatic insufficiency, pancreatitis, hyperthyroidism or hypoadrenocorticism. As discussed earlier, large bowel diarrhoea is almost always due to primary GI disease, whereas small bowel diarrhoea may occur with either primary or secondary GI disease.

Severe systemic diseases such as sepsis and uraemia can cause large bowel diarrhoea, but this will be a very minor clinical sign in relation to the patient’s other systemic clinical signs. Thus, secondary disorders are not usually likely differentials when considering the work‐up of a patient whose primary problem is large bowel diarrhoea.

Diarrhoea due to primary GI disease is more common than diarrhoea due to secondary GI disease. In animals with secondary GI disease, with the exception of exocrine pancreatic insufficiency and some dogs with hypoadrenocorticism, diarrhoea is not usually the primary presenting complaint.

Clinical Reasoning in Veterinary Practice

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