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The main advantage of this method is that the metric acts on the linear representation of the protein and not in the three-dimensional representation of it, making possible a simple analysis. On the other hand, only one physico-chemical property is evaluated, the polarity/charge of the protein.

The analysis is comprehensive as the full spectrum of PIM^® profile incidents is examined; in other words, the PIM^® profile is not a number but a 16-element vector. Thus, two proteins have the same PIM^® profile if their 16-element vectors are equal.