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The PIM^® system (Section 3.5.1) was determined in the four SARS-CoV-2 structural proteins: spike, membrane, envelope, and nucleocapsid (Section 3.3.3), and their smooth curves (Figure 3.1) were plotted, it was observed that there is a similarity in these PIM^® profiles, except for the region between the polar interactions [P⁻, P⁻] and [N, P⁻] see (Figure 3.2).

Figure 3.1 Relative frequency distribution of proteins that express the four SARS-CoV-2 structural viral protein group represented by “smooth curves”. Graphs were produced using EXCEL software. The X-axis represents the 16 charge/polarity interactions. The ellipse shows the region where curves do not match the trend.

Figure 3.2 shows the PIM^® profile of the spike and envelope proteins behaving particularly differently, while the membrane is the translation of nucleocapsid.

A revision of the histograms (Figure 3.3) of the relative frequency distribution of the residues in the sequences of the SARS-CoV-2 structural proteins (spike, envelope, membrane, and nucleocapsid) shows that any of them are similar. When in general, this behavior does not necessarily depend on the length of the sequence.

Figure 3.2 Zoom over the Figure 3.1. The X-axis represents the five polar interactions from [P−, P−] and [N, P−]. See (Section 2.5.4).

Figure 3.3 Histograms SARS-CoV-2 structural proteins.