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The book chapter covered the evidence that changes in the urban lifestyle is one of the major causes leading to obesity and associated chronic diseases including cardiometabolic syndrome, metabolic dysregulations, and also cancer. It is important to formulate strategies on public health based on bearable lifestyle changes and sustainable urbanisation to curb obesity in the population and risk of cardiometabolic syndrome and associated cancer. Lifestyle interventions, weight management, and low‐calorie food intake are crucial to mitigate increasing global burden of obesity, cardiovascular, and metabolic risk factors. Along with this improvement of medical and research facilities to develop anti‐hypertensive and cardio‐protective compounds is a crucial step towards treatment (Kundu et al. 2021a, 2021b). Individual sensitisation and choices are crucial in the case of nutritional intake and the promotion of healthy lifestyle. Government, private, technical, financial, and institutional capacities have to work together for the implementation of adequate land‐use planning, well‐governed cities, and more sustainable infrastructure and environment with open and recreational spaces to mitigate impacts of climate change and unhealthy lifestyles on health. The World Health Organisation has provided a global strategy and action plan to strengthen initiatives for the prevention and control of noncommunicable diseases. Similarly, to curb these life‐threatening disorders individual alertness and population‐based collective approach is the need of the hour.

Paths for bicycling, walking, etc. are also essential. Instead of junk foods, balanced diets can be promoted for regular intake by the children and individuals with genetic backgrounds of developing metabolic syndromes. More research should be commenced urgently to decipher the underlying molecular mechanisms connecting metabolic syndrome with other environmental and societal factors to generate sustainable strategies to develop a better world for the future.