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1 Chapter 1TABLE 1.1 Classifications of representative drug transporters

2 Chapter 2TABLE 2.1 Tissue distribution of organic cation and zwitterion transporters...TABLE 2.2 Selected substrates and inhibitors of the major organic cation an...TABLE 2.3 Common missense variants of SLC22 family cation and zwitterion tr...

3 Chapter 3TABLE 3.1 Prototypical and endogenous substrates of MATE transporters TABLE 3.2 Drug and metabolite substrates of MATE transporters TABLE 3.3 MATE1 and MATE2‐K substrates used in humans TABLE 3.4 MATE1 and MATE2‐K inhibitors identified in human studies TABLE 3.5 Human genetic variation in SLC47A1 and SLC47A2

4 Chapter 4TABLE 4.1 OAT family members a TABLE 4.2 Characterization of Oat1/Oat3 knockout mice with respect to drugs...

5 Chapter 5TABLE 5.1 Human OATPs and tissue expression a TABLE 5.2 Selected human OATP substrates, inhibitors, and stimulators a TABLE 5.3 Selected SLCO genetic variations, pharmacokinetics, and drug resp...

6 Chapter 6TABLE 6.1 A list of mammalian members of the POT family of transporters ado...TABLE 6.2 Summary of the molecular and functional characteristics of establ...

7 Chapter 7TABLE 7.1 Tissue and subcellular expression, substrate specificity, and inh...

8 Chapter 8TABLE 8.1 Molecular and functional characteristics of human nucleoside tran...TABLE 8.2 Apparent affinities (K m ) of various hCNTs and hENTs for adenos...

9 Chapter 10TABLE 10.1 P‐gp substrates and inhibitors a

10 Chapter 11TABLE 11.1 Nomenclature and properties of the human ABCC genes and ABCC pro...TABLE 11.2 Major sites of ABCC/MRP protein expression in normal human tissu...TABLE 11.3 Substrate and drug resistance profiles of human ABCC/MRP transpo...

11 Chapter 12TABLE 12.1 Select substrates and inhibitors of ABCG2 TABLE 12.2 Summary of ABCG2 variants and their effects on transporter func...

12 Chapter 13TABLE 13.1 Human hepatic transporter alterations mediated by nuclear recept...TABLE 13.2 Examples of clinically relevant DDIs with hepatic transporter in...

13 Chapter 15TABLE 15.1 Major human SLC and ABC transporters expressed in renal proximal...

14 Chapter 16TABLE 16.1 Overview of transporter proteins in the human intestinal epithel...TABLE 16.2 Protein abundance of clinically relevant transporter proteins in...TABLE 16.3 Transcriptional regulation by nuclear receptors and epigenetic r...TABLE 16.4 Impact of different pathological conditions on the gene expressi...TABLE 16.5 Examples for clinically relevant drug‐drug interactions that can...

15 Chapter 18TABLE 18.1 Frequency of highlighted drug transporter polymorphisms in diffe...TABLE 18.2 Summary of impact of selected polymorphisms in genes encoding dr...

16 Chapter 19TABLE 19.1 Tissue‐specific maturation patterns for ABC transporters TABLE 19.2 Tissue‐specific maturation patterns for SLC transporters

17 Chapter 20TABLE 20.1 Experimental techniques used to study drug transporters

18 Chapter 22TABLE 22.1 Comparison of SHH and PHH for evaluation of hepatic uptake/efflu...TABLE 22.2 Reported inhibitors for which preincubation with cells potentiat...

19 Chapter 23TABLE 23.1 Common problems in deriving key parameters in Transporter IVIVE‐...TABLE 23.2 Archetypal transporter‐IVIVE scalars, with their incorporation in...

20 Chapter 24TABLE 24.1 SLC transporters as targets in disease TABLE 24.2 ABC transporters as targets in disease

21 Chapter 25TABLE 25.1 Effects of dietary supplements on drug transporters TABLE 25.2 Chemical structures of subclasses of flavonoids TABLE 25.3 Interactions of flavonoids with P‐gp TABLE 25.4 Interactions of flavonoids with MRPs TABLE 25.5 Interactions of flavonoids with BCRP TABLE 25.6 Interactions of flavonoids with OATPs TABLE 25.7 Interactions of isothiocyanates with transporters