Читать книгу Ridley's The Vulva - Группа авторов - Страница 34

The chromosomal makeup is 46,XX with the ovaries and Müllerian duct derivatives as normal. The external genitalia are abnormal. The clitoris is enlarged, variable degrees of labial fusion are seen, and the urethral opening may not be distinct from the vagina. The external genitalia of the male foetus are completely masculinised by 84–98 days. If a female foetus is exposed to significant androgen levels, in the presence of 5∝‐reductase, before the end of this period of development, complete virilisation will occur. Lower levels or later exposure will produce various forms of incomplete virilisation. The source of the androgen excess may be foetal, maternal, or exogenous.