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The main clinical signs associated with intussusception in dogs and cats are anorexia, lethargy and vomiting [2, 3, 5, 9]. Less commonly reported signs include diarrhea with or without blood, hematemesis and weight loss [2, 3, 5, 9]. Animals suffering from gastroesophageal intussusception may present with history of regurgitation and dyspnea [8]. The severity and type of clinical signs are partially dependent on patient factors, duration of the intussusception, and whether the obstruction is complete or incomplete.

Common physical exam findings associated with intussusception include dehydration and abnormal findings on abdominal palpation, such as pain, abdominal mass, or intestinal thickening and distention. Hypothermia may be a common finding in cats, as 40% of cats in one study presented with low body temperatures [3]. Some animals with intussusception may present with signs of shock, such as abnormalities in heart rate, pale mucous membrane color, and poor pulse quality [3, 5].