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1.3.3. Other Functionalization of the α‐Position of Carbonyl Groups
ОглавлениеBifunctional organocatalysts are effective not only for the aldol and Mannich reactions but also for functionalization of the α‐position of carbonyl compounds. α‐Fluorination [21], α‐bromination [22], and α‐iodination [23] of aldehydes are successfully carried out by the use of organocatalyst. Azodicarboxylate is used in the α‐amination of aldehydes catalyzed by proline [24]. α‐Aminoxylation of carbonyls is catalyzed by proline [25] and proline salt [26] using nitrosobenzene as an electrophile. These reactions are summarized in the previous book [6].
