Читать книгу Evidence in Medicine - Iain K. Crombie - Страница 22

A seminal paper by Schulz and colleagues in 1995 showed that studies that reported inadequate concealment treatment allocation exaggerate the estimates of treatment benefit [17]. The initial overview evaluated 250 trials of interventions in pregnancy and childbirth. Since then this finding has been replicated and extended by two overview studies covering thousands of trials across all areas of medicine [7, 18]. Their finding is that poor or inadequately described methods of allocation concealment lead to exaggerated treatment effects.