Читать книгу Principles of Virology, Volume 1 - Jane Flint, S. Jane Flint - Страница 2
Table of Contents
Оглавление1 Cover
2 Preface What’s New Principles Taught in Two Distinct, but Integrated Volumes
6 PART I: The Science of Virology 1 Foundations Luria’s Credo Viruses Defined Why We Study Viruses Virus Prehistory Discovery of Viruses The Defining Properties of Viruses Cataloging Animal Viruses A Common Strategy for Viral Propagation Perspectives References 2 The Infectious Cycle Introduction The Infectious Cycle Viral Pathogenesis Overcoming Host Defenses Cultivation of Viruses Assay of Viruses Viral Reproduction: the Burst Concept The One-Step Growth Cycle Global Analysis Single-Cell Virology Perspectives References
7 PART II: Molecular Biology 3 Genomes and Genetics Introduction Genome Principles and the Baltimore System Structure and Complexity of Viral Genomes What Do Viral Genomes Look Like? Coding Strategies What Can Viral Sequences Tell Us? The “Big and Small” of Viral Genomes: Does Size Matter? The Origin of Viral Genomes Genetic Analysis of Viruses Perspectives References 4 Structure Introduction Building a Protective Coat Packaging the Nucleic Acid Genome Viruses with Envelopes Large Viruses with Multiple Structural Elements Other Components of Virions Mechanical Properties of Virus Particles Perspectives References 5 Attachment and Entry Introduction Attachment of Virus Particles to Cells Entry into Cells Intracellular Trafficking and Uncoating Import of Viral Genomes into the Nucleus Perspectives References 6 Synthesis of RNA from RNA Templates Introduction The Nature of the RNA Template The RNA Synthesis Machinery Mechanisms of RNA Synthesis Paradigms for Viral RNA Synthesis Origins of Diversity in RNA Virus Genomes Perspectives References 7 Synthesis of RNA from DNA Templates Introduction Transcription by RNA Polymerase II Transcription of Viral DNA Templates by the Cellular Machinery Alone Viral Proteins That Govern Transcription of DNA Templates Transcription of Viral Genes by RNA Polymerase III Inhibition of the Cellular Transcriptional Machinery Unusual Functions of Cellular Transcription Components in Virus-Infected Cells Viral DNA-Dependent RNA Polymerases Perspectives References 8 Processing Introduction Covalent Modification during Viral Pre-mRNA Processing Export of RNAs from the Nucleus Posttranscriptional Regulation of Viral or Cellular Gene Expression by Viral Proteins Regulation of Turnover of Viral and Cellular mRNAs in the Cytoplasm Noncoding RNAs Perspectives References 9 Replication of DNA Genomes Introduction DNA Synthesis by the Cellular Replication Machinery Mechanisms of Viral DNA Synthesis Exponential Accumulation of Viral Genomes Limited Replication of Viral DNA Genomes Origins of Genetic Diversity in DNA Viruses Perspectives References 10 Reverse Transcription and Integration Retroviral Reverse Transcription Retroviral DNA Integration Hepadnaviral Reverse Transcription Perspectives References 11 Protein Synthesis Introduction Mechanisms of Eukaryotic Protein Synthesis The Diversity of Viral Translation Strategies Regulation of Translation during Viral Infection Perspectives References 12 Intracellular Trafficking Introduction Assembly within the Nucleus Assembly at the Plasma Membrane Interactions with Internal Cellular Membranes Transport of Viral Genomes to Assembly Sites Perspectives References 13 Assembly, Release, and Maturation Introduction Methods of Studying Virus Assembly and Egress Assembly of Protein Shells Selective Packaging of the Viral Genome and Other Components of Virus Particles Acquisition of an Envelope Release of Virus Particles Maturation of Progeny Virus Particles Cell-to-Cell Spread Perspectives References 14 The Infected Cell Introduction Signal Transduction Gene Expression Metabolism Remodeling of Cellular Organelles Perspectives References
8 APPENDIX: Structure, Genome Organization, and Infectious Cycles of Viruses Featured in This Book Adenoviruses Arenaviruses Coronaviruses Filoviruses Flaviviruses Hepadnaviruses Herpesviruses Orthomyxoviruses Paramyxoviruses Parvoviruses Picornaviruses Polyomaviruses Poxviruses Reoviruses Retroviruses Rhabdoviruses Togaviruses
9 Glossary
10 Index
