Читать книгу Principles of Virology, Volume 1 - Jane Flint, S. Jane Flint - Страница 64

Viral infection is initiated by a collision between the virus particle and the cell, a process that is governed by chance. A virion may not infect every cell it encounters: it must first come in contact with the tissues that contain cells to which it can bind. Such cells are normally recognized by means of the specific interaction of a virus particle with a cell surface receptor. These cellular molecules do not exist for the benefit of viruses: they all perform functions for the cell. Virus-receptor interactions can be either promiscuous or highly selective, depending on the virus and the distribution of the cell receptor. The presence of such receptors determines whether the cell will be susceptible to the virus. However, whether a cell is permissive for the reproduction of a particular virus depends on other, intracellular components found only in certain cell types. Cells must be both susceptible and permissive if an infection is to be successful. Virus entry into cells is the topic of Chapter 5.