Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 226

The examples provided above highlight the diversity of cell surface molecules that can serve as viral receptors and demonstrate that entry of many viruses requires more than one cell surface molecule. In contrast, some nonenveloped virus particles bind to different cell receptors, depending on the nature of the virus isolate or the cell line. Often passage of viruses in cells in culture selects variants that bind heparan sulfate. Infection of cells with foot-and-mouth disease virus type A12 requires integrin α_vβ₃. However, the receptor for the O strain of this virus, which has been extensively passaged in cells in culture, is not integrin α_vβ₃ but cell surface heparan sulfate. On the other hand, the type A12 strain cannot infect cells that lack integrin α_vβ₃, even if heparan sulfate is present.