Читать книгу Principles of Virology - Jane Flint, S. Jane Flint - Страница 241

Following entry, viral and subviral particles travel within the cell to compartments appropriate for virus genome replication. Transport relies on cellular networks. For enveloped virus particles that fuse at the plasma membrane, the transport cargo is subviral particles, whereas for those that fuse in internal cellular compartments, transport, at least in part, is achieved by processes that move vesicles. At some point during or after transport, uncoating occurs so that the viral genome is released from the viral capsid and can replicate. The genomes of nonenveloped viruses are transferred across the cell membrane by mechanisms different than membrane fusion. For these viruses, the processes of entry and uncoating are tightly linked.